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Open Access Research

Frontostriatal functional connectivity in major depressive disorder

Daniella J Furman*, J Paul Hamilton and Ian H Gotlib

Author Affiliations

Department of Psychology, Stanford University, 450 Serra Mall, Stanford, CA 94305-2004, USA

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Biology of Mood & Anxiety Disorders 2011, 1:11  doi:10.1186/2045-5380-1-11

Published: 8 December 2011

Additional files

Additional file 1:

Estimates (and standard errors) of functional connectivity between striatal regions-of-interest and frontal cortical regions for control, medicated depressed, and non-medicated depressed participants. Frontal cortical region clusters were identified in the between-groups (control vs depressed) analyses; for each participant, Fisher transformed correlation coefficients were averaged across all voxels falling within a given cluster. In no analysis did medicated and non-medicated depressed participants differ significantly from each other. CTL = control; MDD = major depressive disorder; PFC = prefrontal cortex; sACC = subgenual anterior cingulate cortex.

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Additional file 2:

Functional connectivity with striatal seeds: control (CTL) group. Voxel-wise p < 0.005, minimum cluster size = 26 voxels. ACC = anterior cingulate cortex; DC = dorsal caudate; DCP = dorsal caudal putamen; PFC = prefrontal cortex; VRP = ventral rostral putamen; VS = ventral striatum.

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Additional file 3:

Functional connectivity with striatal seeds: major depressive disorder (MDD) group. Voxel-wise p < 0.005, minimum cluster size = 26 voxels. ACC = anterior cingulate cortex; DC = dorsal caudate; DCP = dorsal caudal putamen; PFC = prefrontal cortex; VRP = ventral rostral putamen; VS = ventral striatum.

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Open Data