Table 1

Between-group differences in striatal connectivity

Seed

Contrast

Region

Peak voxel (Talairach)

Cluster size

Peak t value


x

y

z


VS

CTL > MDD

Left subgenual ACC, medial orbitofrontal cortex

-13

41

-4

40

3.9

MDD > CTL

Left precuneus, posterior cingulate cortex

-7

-46

32

39

4.1

Right cerebellum

29

-25

-28

31

4.4

Right inferior parietal lobule

35

-49

38

30

3.9

DC

CTL > MDD

Left medial frontal gyrus

-7

53

-1

32

3.6

MDD > CTL

Right middle frontal gyrus

32

32

26

44

4.0

VRP

CTL > MDD

Left superior temporal gyrus

-58

-13

-1

93

4.2

Left medial frontal gyrus, orbitofrontal cortex

-16

35

-10

78

4.5

Right posterior insula

44

-13

8

30

4.0

MDD > CTL

Right caudate body, subgyral

17

14

20

52

4.4

DCP

CTL > MDD

Left superior temporal gyrus

-55

2

-7

50

5.1

Right superior temporal gyrus

53

5

-10

46

4.6

Right posterior insula

41

-16

11

44

4.4

Right middle temporal gyrus

53

-64

14

41

3.8

MDD > CTL

Left inferior parietal lobule, postcentral gyrus

-46

-37

50

80

4.8

Right inferior parietal lobule

41

-46

47

54

4.7

Right lingual gyrus

26

-85

-13

38

4.4


Voxel-wise p < 0.005, minimum cluster size = 26 voxels.

ACC = anterior cingulate cortex; CTL = control; DC = dorsal caudate; DCP = dorsal caudal putamen; MDD = major depressive disorder; VRP = ventral rostral putamen; VS = ventral striatum.

Furman et al. Biology of Mood & Anxiety Disorders 2011 1:11   doi:10.1186/2045-5380-1-11

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