Figure 3.

5-HT1A BPND significantly moderated the correlation between 5-HT2A BPND and right amygdala reactivity. (A) pgPFC 5-HT1A BPND moderated the correlation between pgPFC 5-HT2A BPND and right amygdala reactivity. Lines indicate simple slope between pgPFC 5-HT2A BPND and right amygdala reactivity at three arbitrarily chosen pgPFC 5-HT1A BPND values: low (1 SD below mean (-1 SD), solid black line), mean (equivalent to mean, red dotted line) and high (1 SD above mean (+1 SD), green dotted line). (B) sgPFC 5-HT1A BPND significantly moderated the association between sgPFC 5-HT2A BPND and right amygdala reactivity. Lines indicate simple slope between sgPFC 5-HT2A BPND and right amygdala reactivity at three arbitrarily chosen sgPFC 5-HT1A BPND values: low (-1 SD, solid black line), mean (red dotted line) and high (+1 SD, green dotted line). *Indicates simple slope, P < 0.05; 5-HT = serotonin; a.u. = arbitrary units; BPND = binding potential, non-displaceable; pgPFC = pregenual prefrontal cortex; sgPFC = subgenual prefrontal cortex.

Fisher et al. Biology of Mood & Anxiety Disorders 2011 1:2   doi:10.1186/2045-5380-1-2
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