Figure 4.

Schematic illustrating mPFC projection neurons that act to regulate amygdala response to threat-related stimuli. 5-HT_1A and 5-HT_2A in mPFC are positioned to modulate this circuitry by biasing excitability of these mPFC neurons, thereby affecting the capacity to regulate amygdala reactivity. 5-HT = serotonin; mPFC = medial prefrontal cortex; CeL = lateral central nucleus of the amygdala; CeM = medial central nucleus of the amygdala; ITC = intercalated cells.