Schematic illustrating mPFC projection neurons that act to regulate amygdala response to threat-related stimuli. 5-HT1A and 5-HT2A in mPFC are positioned to modulate this circuitry by biasing excitability of these mPFC neurons, thereby affecting the capacity to regulate amygdala reactivity. 5-HT = serotonin; mPFC = medial prefrontal cortex; CeL = lateral central nucleus of the amygdala; CeM = medial central nucleus of the amygdala; ITC = intercalated cells.
Fisher et al. Biology of Mood & Anxiety Disorders 2011 1:2 doi:10.1186/2045-5380-1-2