Table 3 |
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Summary of diffusion tensor imaging studies included in our meta-analysis conducted in patients with major depressive disorder using corrected whole-brain voxel-based analysisa |
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|
Study |
Method |
Participants |
Results |
Comments |
|
|
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|
Kieseppä et al. [18] |
Voxel-based analysis 1.5 Tesla 12 non-colinear directions |
16 middle-aged MDD patients and 20 controls |
Reduced FA in the left sagittal stratum, cingulate cortex and posterior corpus callosum |
Reduced FA in left SLF (temporoparietal) and in the right cingulum in patients with MDD |
|
Zhu et al. [58] |
TBSS 1.5 Tesla 13 non-colinear directions |
25 young first-episode MDD patients and 25 matched controls |
Reduced FA in the left anterior limb of the internal capsule, right parahippocampal gyrus and left posterior cingulate cortex |
FA values in the left anterior limb of the internal capsule and right cingulum (hippocampus) and left cingulum (dorsal part) were negatively correlated with symptom severity |
|
Abe et al. [59] |
Voxel-based analysis 1.5 Tesla 6 non-colinear directions |
21 young MDD patients and 42 controls |
No significant difference between groups for FA and WM volume |
Negative correlation between FA and total days depressed in both the right anterior cingulate and the left frontal WM |
|
Blood et al. [24] |
Voxel-based analysis 3.0 Tesla 6 non-colinear directions |
22 MDD patients and 22 controls |
Increased FA in the right ventral tegmental area and reduced FA in DLPFC WM in MDD subjects |
Increased FA in right corticospinal tract, decreased FA in left corticospinal tract, right inferior FOF (frontal lobe), bilateral DLPFC, left SLF (temporal) |
|
Wu et al. [25] |
Voxel-based analysis 3.0 Tesla 13 non-colinear directions |
23 single-episode, medication-naive MDD subjects and 21 controls |
FA reduction in right SLF, right middle frontal and left parietal WM with MDD |
Reduced FA in left SLF (parietal lobe) and right frontal WM with MDD |
|
Jia et al. [26] |
Voxel-based analysis 3.0 Tesla 15 non-colinear directions |
52 MDD patients, 16 with and 36 without a history of suicide attempts, and 52 matched controls |
Reduced FA in the left anterior limb of the internal capsule in suicide attempters relative to both nonattempters and controls |
Reduced FA in bilateral SLF (parietal lobe) and cerebellum |
|
Korgaonkar et al. [60] |
Voxel-based analysis 3.0 Tesla 42 different diffusion orientations |
29 MDD subjects and 39 controls |
7.8% reduction in FA in the limbic system, DLPFC, thalamic projection fibres, and corpus callosum |
Limbic-DLPFC-thalamic axis Dysfunction may be involved in MDD |
|
|
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|
aMDD, major depressive disorder; FA, fractional anisotropy; SLF, superior longitudinal fasciculus; TBSS, tract-based spatial statistics; FOF, fronto-occipital fasciculus; DLPFC, dorsolateral prefrontal cortex; WM, white matter. |
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Murphy and Frodl Biology of Mood & Anxiety Disorders 2011 1:3 doi:10.1186/2045-5380-1-3 |
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