Table 1

Studies examining the P50 and sensory gating






46 prisoners of war

36 healthy controls

Checkerboard reversal (visual)

Significantly greater P50 amplitude and latency


10 inpatient combat PTSD

5 inpatient alcohol-dependents

5 combat-exposed and

5 combat-non-exposed

healthy subjects

Paired click

Diminished P50 habituation in PTSD


13 female with sexual assault PTSD 16 healthy controls

Auditory oddball

No difference in P50 peak amplitude and latency


15 combat veterans

12 healthy control

Paired click

P50 amplitude in response to the conditioning stimulus did not differ. P50 T/C ratio was increased in PTSD subjects.


10 male veteran PTSD + 9 female rape victims matched control groups

Paired click

Decreased P50 gating


29 PTSD nurse veterans

38 non-PTSD

Paired click

Reduced P50 suppression associated with increased severity of general psychopathology, but not with PTSD.


12 urban violence PTSD/24 healthy subjects/12 schizophrenics

Paired click

Higher P50 ratios in subjects with PTSD


27 civilian with mixed types of trauma and 24 control subjects

Paired click

Impaired P50 suppression in PTSD subjects


Seven combat veterans with PTSD and 11 matched controls

Paired click

Impaired M50 gating in the right hemisphere in PTSD subjects. Thinner right STG (Superior Temporal Gyrus) cortical thickness was associated with worse right sensory gating in the PTSD group. The right S1 P50 source strength and gating ratio were correlated with PTSD symptomatology.

Javanbakht et al. Biology of Mood & Anxiety Disorders 2011 1:5   doi:10.1186/2045-5380-1-5

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