Table 3

Summary of the studies which included P200 component

Study

Study Groups

Paradigm

Findings


[31]

12 combat PTSD veterans

6 normal controls

Four tones intensity paradigm

Reduced P2 amplitude intensity slope in PTSD subjects


[25]

13 female with sexual assault PTSD

16 healthy controls

Auditory oddball

Reduced amplitude and latency in response to deviant stimuli


[28]

17 civil PTSD

17 healthy controls

Auditory oddball

Smaller P200 to target and common tones. Earlier response to common but not target tones.


[30]

36 civil PTSD

20 healthy

10 depressed

8 alcoholics.

2000-Hz tone presented in intensity blocks of 65, 72.5, 80, 87.5, and 95 dB (SPL)

In normal subjects, depressed, and alcoholics, there was linear relationship between the tone intensity and P200 amplitude, which was not the case in combat related PTSD subjects.


[32]

29 PTSD nurse veterans

38 non-PTSD

Four-tone stimulus-intensity modulation paradigm

Increased P2 amplitude/intensity slope


[35]

10 civil PTSD

10 controls

Auditory oddball

No difference in P2 amplitude or latency


[29]

7 PTSD motor vehicle accident (MVA)

7 non-PTSD with MVA

Visual presentation of trauma related/unrelated/neutral pictures

Smaller P200 amplitude

Larger response to trauma-related images in non-PTSD and healthy controls


[36]

14 PTSD [mixed etiologies]

12 controls

Auditory oddball

No difference in P200 amplitude


[33]

12 combat exposed veterans with PTSD and 33 without PTSD and their twins

Four-tone stimulus-intensity modulation paradigm

Increased P2 amplitude intensity slope in PTSD veterans.

P2 amplitude intensity slopes were related to higher combat exposure, CAPS Total, and re-experience symptoms severity scores in the

combat-exposed veterans but not to the remaining PTSD symptom cluster scores or the SCL-90-R (Symptom Checklist 90 Revised) general psychopathology, anxiety, or depression subscale scores.

Higher combat-exposure scores, but not CAPS Total or subscale scores, were also related to increased P2 amplitude.


[34]

12 PTSD and 12 control survivors of earthquake

Subliminal visual presentation of earthquake-related/unrelated words

Increased P2 amplitude in the PTSD group in response to the trauma-related stimuli


Javanbakht et al. Biology of Mood & Anxiety Disorders 2011 1:5   doi:10.1186/2045-5380-1-5

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