Table 5

Summary of studies with clinical correlates


Clinical scales

Clinical correlates


IES, PTSD questionnaire

Positive correlation between P300 latency at Pz and Cz and the judged severity of intrusiveness measured by IES (Impact of Event Scale). Same applies to the level of intrusiveness measured by PTSD questionnaire.

Negative correlation between P300 latency at Cz and severity of avoidance.



P50 gating correlated negatively and significantly with PTSD subjects' CAPS re-experiencing intensity scores.



Measures of state anxiety (STAI) were significantly related to P300 amplitude at Pz; higher levels of self-reported state anxiety were associated with smaller P300 amplitudes.



P300 amplitudes to emotionally meaningful words were significantly related to Clinician-Administered PTSD Scale subscales, in particular avoidance and arousal.


Mississippi score, STAI

Significant correlation between the magnitude of the MMN at Fz and the Mississippi PTSD Symptom Scale for civilian trauma.



No significant correlations were found between P50 gating and IES-R or CAPS total or subscale scores.



Significant correlation between the intensity of numbing symptoms (reduced interest, social withdrawal, and emotional numbing) and P300 amplitude at parietal sites.



PTSD subjects who showed N100 augmentation and P200 reduction were more depressed than PTSD patients with other patterns.

Significant correlations between P200 slope and Clinician-Administered PTSD Scale total score, the Mississippi scale score, and the Hamilton depression score




P2 slope was positively correlated with PCL-M, CAPS Total, and each of the CAPS subscale scores, indicating that a higher P2 slope was associated with more severe PTSD symptomatology

P50 gating was negatively correlated with SCL-90-R Global Severity Index (GSI) score, indicating that worse gating is associated with more severe general psychopathology.


CAPS, IES-R, BDI, Mood State (POMS)

P300 amplitude to novel auditory stimuli increased as tension score in POMS increased.



Significantly negative correlation between present score of the cluster C of the CAPS (numbness/avoidance) and P300 amplitude at Pz.


STAI, BDI (Beck Depression Inventory), CAPS

Negative relationship between P550 amplitude and trait anxiety. Negative relationship between P550 amplitude and depression CAPS scores; negative relationship between P550 amplitude and intrusions.


Brief Symptom Inventory (BSI),

MMN was significantly correlated with the total PTSD score.



Neither P300 nor behavioral measures were related to CAPS symptom severity measures.

Javanbakht et al. Biology of Mood & Anxiety Disorders 2011 1:5   doi:10.1186/2045-5380-1-5

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