Table 1

Clinical and volumetric data and statistical differences between the post-traumatic stress disorder (PTSD) and healthy control groups

PTSD

Healthy controls

Comparison (statistic, df, P value)


N

22

75

-


Age

34.8 ± 10.4

36.9 ± 11.9

t = 0.7, 95, 0.472


Gender (% female)

77%

61%

χ2 = 1.9, 1, 0.168


Handedness (r/l)

18/4

72/3

χ2 = 5.1, 1, 0.024*


Trauma exposure (childhood/adult)

9/13

NA

-


Type of trauma (sexual abuse/physical abuse/other)

10/6/6

NA

-


Concurrent MDD episode (yes/no)

11/11

NA

-


History of substance abuse (yes/no)

2/20

NA

-


IDS score

21.4 ± 14.1

0.7 ± 1.3

t = 8.9, 57, < 0.001**


CAPS score

76.4 ± 16.6

NA

-


HAM-A score

10.3 ± 6.1

0.4 ± 0.8

t = 12.0, 75, < 0.001**


Total brain volume (mm3)

1 144 067 ± 94962

1 174 544 ± 118 902

F = 1.2, 1, 0.278


Left habenula volume (mm3)

18.8 ± 3.6

19.8 ± 5.1

F = 0.8, 1, 0.384


Normalized left habenula volume

0.000016 ± 0.0000036

0.000017 ± 0.0000052

F = 0.1, 1, 0.999


Right habenula volume (mm3)

16.4 ± 3.7

17.1 ± 4.6

F = 0.2, 1, 0.688


Normalized right habenula volume

0.000014 ± 0.0000032

0.000015 ± 0.0000044

F = 0.1, 1, 0.999


Total habenula volume (mm3)

35.2 ± 6.7

36.9 ± 8.5

F = 0.7, 1, 0.403


Normalized total habenula volume

0.000031 ± 0.0000062

0.000032 ± 0.0000094

F = 0.3, 1, 0.589


CAPS = Clinician-Administered PTSD Scale; IDS = Inventory of Depressive Symptomatology; HAM-A = Hamilton Anxiety Rating scale; MDD = major depressive disorder; NA = not applicable.

* p < 0.05

** p < 0.01

Savitz et al. Biology of Mood & Anxiety Disorders 2011 1:7   doi:10.1186/2045-5380-1-7

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