Table 1 |
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|
Clinical and volumetric data and statistical differences between the post-traumatic stress disorder (PTSD) and healthy control groups |
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|
PTSD |
Healthy controls |
Comparison (statistic, df, P value) |
|
|
|
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|
N |
22 |
75 |
- |
|
|
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|
Age |
34.8 ± 10.4 |
36.9 ± 11.9 |
t = 0.7, 95, 0.472 |
|
|
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|
Gender (% female) |
77% |
61% |
χ2 = 1.9, 1, 0.168 |
|
|
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|
Handedness (r/l) |
18/4 |
72/3 |
χ2 = 5.1, 1, 0.024* |
|
|
|||
|
Trauma exposure (childhood/adult) |
9/13 |
NA |
- |
|
|
|||
|
Type of trauma (sexual abuse/physical abuse/other) |
10/6/6 |
NA |
- |
|
|
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|
Concurrent MDD episode (yes/no) |
11/11 |
NA |
- |
|
|
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|
History of substance abuse (yes/no) |
2/20 |
NA |
- |
|
|
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|
IDS score |
21.4 ± 14.1 |
0.7 ± 1.3 |
t = 8.9, 57, < 0.001** |
|
|
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|
CAPS score |
76.4 ± 16.6 |
NA |
- |
|
|
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|
HAM-A score |
10.3 ± 6.1 |
0.4 ± 0.8 |
t = 12.0, 75, < 0.001** |
|
|
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|
Total brain volume (mm3) |
1 144 067 ± 94962 |
1 174 544 ± 118 902 |
F = 1.2, 1, 0.278 |
|
|
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|
Left habenula volume (mm3) |
18.8 ± 3.6 |
19.8 ± 5.1 |
F = 0.8, 1, 0.384 |
|
|
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|
Normalized left habenula volume |
0.000016 ± 0.0000036 |
0.000017 ± 0.0000052 |
F = 0.1, 1, 0.999 |
|
|
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|
Right habenula volume (mm3) |
16.4 ± 3.7 |
17.1 ± 4.6 |
F = 0.2, 1, 0.688 |
|
|
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|
Normalized right habenula volume |
0.000014 ± 0.0000032 |
0.000015 ± 0.0000044 |
F = 0.1, 1, 0.999 |
|
|
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|
Total habenula volume (mm3) |
35.2 ± 6.7 |
36.9 ± 8.5 |
F = 0.7, 1, 0.403 |
|
|
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|
Normalized total habenula volume |
0.000031 ± 0.0000062 |
0.000032 ± 0.0000094 |
F = 0.3, 1, 0.589 |
|
|
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|
CAPS = Clinician-Administered PTSD Scale; IDS = Inventory of Depressive Symptomatology; HAM-A = Hamilton Anxiety Rating scale; MDD = major depressive disorder; NA = not applicable. * p < 0.05 ** p < 0.01 |
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Savitz et al. Biology of Mood & Anxiety Disorders 2011 1:7 doi:10.1186/2045-5380-1-7 |
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