Table 3

Univariate analysis results

    Contrast

ROIa

MNIb, peak x, y, z

Z-score

Size, voxels

Cluster P value, FWEc

Region


    US
    d

PTSDe > TENCf

Whole brain

-22, 0, -6

5.51

111

< 0.0001

Left putamen

(-24, 10, -14)

-5.47

(-32, 2, -4)

-4.93

18, 10 -12

5.47

90

< 0.0001

Right putamen

(20, 10, -4)

-5.13

-22, -4, 48

5.25

19

0.003

Left middle frontal gyrus

-18, -38, -4

5.07

11

0.007

Left parahippocampal gyrus

Putamen

16, 12, -10

5.34

359

< 0.0001

Right ventral putamen

(30, -20, 6)

-3.79

(28, -2, -6)

-3.73

-26, 2, -4

5.11

840

< 0.0001

Left putamen

(-22, 8, -10)

-4.88

(-32, -12, -6)

-4.75

Amygdala

-22, 6, -16

4.3

48

0.01

Left amygdala

24, 2, -16

4.27

81

0.005

Right amygdala

Hippocampus

-18, -32, 4

4.43

36

0.029

Left hippocampus

(-22, -24, -8)

-3.74

-26, -34, 8

3.79

18

0.028

Left hippocampus

(-14, -32, 10)

-3.52

-26, -12, -12

3.69

25

0.042

Left hippocampus

(-20, -4, 12)

-3.62

Cingulate

8, 12, 42

3.8

19

0.013

Right dorsal acc

Insula

34, -20, 4

4.97

36

0.006

Right posterior insula

-26, 14, -16

5.05

28

0.008

Left piriform insula

-34, -6, 16

4.14

13

0.017

Left middle insula

-36, -22, 4

4.08

17

0.014

Left posterior insula

Caudate

-14, 16, -8

4.2

67

0.006

Right caudate

(16, 18, 0)

-3.81

16, 0, 16

3.86

24

0.021

Right caudate

-12, 10, 14

4.41

297

0.001

Left caudate body

(-18, -2, 22)

-4.16

TENC > PTSD

No significant differences in whole brain or ROI

    Omitted US

PTSD > TENC

Whole brain

No significant differences in whole brain

Hippocampus

22, -10, -20

3.77

54

0.009

Right anterior hippocampus

(30, -10, -18)

-3.46

TENC > PTSD

No significant differences in whole brain or ROI

    US minus omitted US

PTSD > TENC

Whole brain

No significant differences in whole brain

Putamen

20, 12, -10

3.89

69

0.003

Right ventral putamen

20, 0, 12

3.48

13

0.032

Insula

-28, 16, -18

4.05

52

0.016

Left orbital insula


Clusters are in bold, with sub-peaks in brackets.

aRegion of interest

bMontreal Neurological Institute.

cFamily-wise error.

dUS, unconditioned stimulus

ePost-traumatic stress disorder.

fTrauma-exposed normal control.

Linnman et al. Biology of Mood & Anxiety Disorders 2011 1:8   doi:10.1186/2045-5380-1-8

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