Table 3 |
|||||
|
Univariate analysis results |
|||||
|
Contrast ROIa |
MNIb, peak x, y, z |
Z-score |
Size, voxels |
Cluster P value, FWEc |
Region |
|
|
|||||
|
USd |
|||||
|
PTSDe > TENCf |
|||||
|
Whole brain |
-22, 0, -6 |
5.51 |
111 |
< 0.0001 |
Left putamen |
|
(-24, 10, -14) |
-5.47 |
||||
|
(-32, 2, -4) |
-4.93 |
||||
|
18, 10 -12 |
5.47 |
90 |
< 0.0001 |
Right putamen |
|
|
(20, 10, -4) |
-5.13 |
||||
|
-22, -4, 48 |
5.25 |
19 |
0.003 |
Left middle frontal gyrus |
|
|
-18, -38, -4 |
5.07 |
11 |
0.007 |
Left parahippocampal gyrus |
|
|
Putamen |
16, 12, -10 |
5.34 |
359 |
< 0.0001 |
Right ventral putamen |
|
(30, -20, 6) |
-3.79 |
||||
|
(28, -2, -6) |
-3.73 |
||||
|
-26, 2, -4 |
5.11 |
840 |
< 0.0001 |
Left putamen |
|
|
(-22, 8, -10) |
-4.88 |
||||
|
(-32, -12, -6) |
-4.75 |
||||
|
Amygdala |
-22, 6, -16 |
4.3 |
48 |
0.01 |
Left amygdala |
|
24, 2, -16 |
4.27 |
81 |
0.005 |
Right amygdala |
|
|
Hippocampus |
-18, -32, 4 |
4.43 |
36 |
0.029 |
Left hippocampus |
|
(-22, -24, -8) |
-3.74 |
||||
|
-26, -34, 8 |
3.79 |
18 |
0.028 |
Left hippocampus |
|
|
(-14, -32, 10) |
-3.52 |
||||
|
-26, -12, -12 |
3.69 |
25 |
0.042 |
Left hippocampus |
|
|
(-20, -4, 12) |
-3.62 |
||||
|
Cingulate |
8, 12, 42 |
3.8 |
19 |
0.013 |
Right dorsal acc |
|
Insula |
34, -20, 4 |
4.97 |
36 |
0.006 |
Right posterior insula |
|
-26, 14, -16 |
5.05 |
28 |
0.008 |
Left piriform insula |
|
|
-34, -6, 16 |
4.14 |
13 |
0.017 |
Left middle insula |
|
|
-36, -22, 4 |
4.08 |
17 |
0.014 |
Left posterior insula |
|
|
Caudate |
-14, 16, -8 |
4.2 |
67 |
0.006 |
Right caudate |
|
(16, 18, 0) |
-3.81 |
||||
|
16, 0, 16 |
3.86 |
24 |
0.021 |
Right caudate |
|
|
-12, 10, 14 |
4.41 |
297 |
0.001 |
Left caudate body |
|
|
(-18, -2, 22) |
-4.16 |
||||
|
TENC > PTSD |
No significant differences in whole brain or ROI |
||||
|
Omitted US |
|||||
|
PTSD > TENC |
|||||
|
Whole brain |
No significant differences in whole brain |
||||
|
Hippocampus |
22, -10, -20 |
3.77 |
54 |
0.009 |
Right anterior hippocampus |
|
(30, -10, -18) |
-3.46 |
||||
|
TENC > PTSD |
No significant differences in whole brain or ROI |
||||
|
US minus omitted US |
|||||
|
PTSD > TENC |
|||||
|
Whole brain |
No significant differences in whole brain |
||||
|
Putamen |
20, 12, -10 |
3.89 |
69 |
0.003 |
Right ventral putamen |
|
20, 0, 12 |
3.48 |
13 |
0.032 |
||
|
Insula |
-28, 16, -18 |
4.05 |
52 |
0.016 |
Left orbital insula |
|
|
|||||
|
Clusters are in bold, with sub-peaks in brackets. aRegion of interest bMontreal Neurological Institute. cFamily-wise error. dUS, unconditioned stimulus ePost-traumatic stress disorder. fTrauma-exposed normal control. |
|||||
|
Linnman et al. Biology of Mood & Anxiety Disorders 2011 1:8 doi:10.1186/2045-5380-1-8 |
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