Table 4

Psychophysiological interaction analysis

Seed

MNIa, peak x, y, z

Z-score

Size, voxels

Cluster P value, FWEb

Regionc


Left putamen

TENCd > PTSDe

-44, -12, -16

4.65

295

0.01

Left temporal lobe

(-32, 0, -30)

4.01

Left parahippocampal lobe/amygdala

(-30, -10, -22)

3.72

Left parahippocampal gyrus

PTSD > TENC

No significant differences

Right putamen

TENC > PTSD

-30, 0, -32

4.54

248

0.019

Left temporal lobe wm/amygdala

(-48, 8, -30)

3.97

Left middle temporal gyrus

(-56, 4, -26)

3.44

Left middle temporal gyrus

PTSD > TENC

No significant differences

Left middle frontal gyrus

TENC > PTSD

No significant differences

PTSD > TENC

No significant differences

Left parahippocampal gyrus

TENC > PTSD

44, -34, 42

4.45

449

0.001

Right inferior parietal lobule

48, -38, 50

-4.27

Right inferior parietal lobule

52, -26, 50

-3.77

Right postcentral gyrus

-10, 66, 10

4.42

263

0.017

Left medial frontal gyrus

(-14, 62, 0)

-4.06

Left medial frontal gyrus

(-8, 62, 18)

-3.45

Left medial frontal gyrus

34, -20, 68

4.37

487

0.001

Right precentral gyrus

(34, -16, 46)

-4.14

Right precentral gyrus

(22, -16, 74)

-4.12

Right precentral gyrus

PTSD > TENC

No significant differences


aMontreal Neurological Institute.

bFamily-wise error.

cRegions were identified based on nearest gray matter.

dPost-traumatic stress disorder.

eTrauma-exposed normal control.

Linnman et al. Biology of Mood & Anxiety Disorders 2011 1:8   doi:10.1186/2045-5380-1-8

Open Data