Table 3

Paired comparisons between healthy controls (HC, n = 24), family history negative healthy participants (FHN, n = 14), family history positive healthy participants (FHP, n = 10) and patients with major depressive disorder (MDD, n = 14)

Contrast

Comparison

Region

Region of interest P (FWE correction)

Ke

T

Puncorrected

x

y

z


F > N

MDD < HC

Left middle cingulum

0.041 (cluster corr.)

71

3.82

< 0.001

-15

-28

37

Left insula

0.072

8

4.19

< 0.001

-27

29

7

MDD < FHN

Left insula

< 0.033

11

4.43

< 0.001

-27

29

7

Left post-central gyrus

ns

29

3.59

< 0.001

-27

-28

37

MDD > FHN

-

ns

-

-

ns

-

-

-

MDD < FHP

-

ns

-

-

ns

-

-

-

MDD > FHP

-

ns

-

-

ns

-

-

-

FHP > FHN

Right Heschl's gyrus

0.018

17

4.60

< 0.001

51

-28

13

FHP < FHN

-

ns

-

-

ns

-

-

-

F < N

FHP < FHN

Right Heschl's gyrus

0.002

26

5.22

< 0.001

51

-28

13

MDD < FHP

-

ns

-

-

ns

-

-

-

MDD > FHP

-

ns

-

-

ns

-

-

-


F > N: "fear" > "neutral" contrast; F < N: "fear" < "neutral" contrast; FWE: family wise error correction; Ke: number of significant voxels; ns: not significant; T: t-value; x, y, z: coordinates in the Montreal Neurological Institute system.

Amico et al. Biology of Mood & Anxiety Disorders 2012 2:1   doi:10.1186/2045-5380-2-1

Open Data