Table 3 |
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|
Paired comparisons between healthy controls (HC, n = 24), family history negative healthy participants (FHN, n = 14), family history positive healthy participants (FHP, n = 10) and patients with major depressive disorder (MDD, n = 14) |
|||||||||
|
Contrast |
Comparison |
Region |
Region of interest P (FWE correction) |
Ke |
T |
Puncorrected |
x |
y |
z |
|
|
|||||||||
|
F > N |
MDD < HC |
Left middle cingulum |
0.041 (cluster corr.) |
71 |
3.82 |
< 0.001 |
-15 |
-28 |
37 |
|
Left insula |
0.072 |
8 |
4.19 |
< 0.001 |
-27 |
29 |
7 |
||
|
MDD < FHN |
Left insula |
< 0.033 |
11 |
4.43 |
< 0.001 |
-27 |
29 |
7 |
|
|
Left post-central gyrus |
ns |
29 |
3.59 |
< 0.001 |
-27 |
-28 |
37 |
||
|
MDD > FHN |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
MDD < FHP |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
MDD > FHP |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
FHP > FHN |
Right Heschl's gyrus |
0.018 |
17 |
4.60 |
< 0.001 |
51 |
-28 |
13 |
|
|
FHP < FHN |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
F < N |
FHP < FHN |
Right Heschl's gyrus |
0.002 |
26 |
5.22 |
< 0.001 |
51 |
-28 |
13 |
|
MDD < FHP |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
MDD > FHP |
- |
ns |
- |
- |
ns |
- |
- |
- |
|
|
|
|||||||||
|
F > N: "fear" > "neutral" contrast; F < N: "fear" < "neutral" contrast; FWE: family wise error correction; Ke: number of significant voxels; ns: not significant; T: t-value; x, y, z: coordinates in the Montreal Neurological Institute system. |
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|
Amico et al. Biology of Mood & Anxiety Disorders 2012 2:1 doi:10.1186/2045-5380-2-1 |
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