BOLD responses to social evaluative threat by diagnostic group in the medial frontal cortex. Each graph plots activation across time: EWMA z = exponentially weighted moving average z-statistic (temporally smoothed deviations from baseline period). Base = baseline, Instruc = instructions period, Prep = speech preparation period, and Rec = recovery period. Solid black bars designate the time-points for which there was a main effect of being diagnosed with depression vs. not having depression; insets show these data with standard error bars. BOLD = blood oxygenation level dependent.
Waugh et al. Biology of Mood & Anxiety Disorders 2012 2:11 doi:10.1186/2045-5380-2-11