Table 4
Change-point analysis of the BOLD responses to the social evaluative threat task of participants with and without major depressive disorder
Region x y z voxels vol (mm3) Peak t change-point onset change-point offset comorbid (~,>,<) pure depression1
Depression > No Depression
Instructions
r. Insula 38 8 −2 71 1917 7.09 74 82 <
l. Precentral G.* −50 4 4 54 1458 5.84 99 115 <
l. Precentral G.* −56 −8 16 15 405 5.83 73 81 <
l. Middle Frontal G. −40 34 16 14 378 6.88 62 70 ~
Medial Frontal G. 4 34 26 88 2376 7.58 62 77 ~
l. Inferior Frontal G. −50 −2 26 19 513 6.79 77 88
Cingulate G.* 2 4 28 50 1350 6.88 62 81 <
Cingulate G. −14 −4 26 26 702 5.9 71 81
Cingulate G. 10 −10 28 24 648 6.11 65 83 <
Early Speech Prep
l. Precentral G. −56 −4 8 36 972 5.97 100 114 ~
l. Prefrontal G. −50 4 16 20 540 5.54 104 112 ~
Cingulate G. 16 −28 38 16 432 6.35 103 111 ~
Late Speech Prep
l. Insula −34 −16 14 14 378 5.56 152 160
r. Insula 34 −8 22 76 2052 6.01 148 162
l. Postcentral G. −52 −22 22 24 648 6.54 157 163 ~
r. Caudate 14 2 20 33 891 5.97 151 161
Cingulate G. 10 34 20 15 405 6.69 144 152
l. Sub-gyral −34 −20 34 31 837 5.88 148 162 ~
l. Sub-gyral* −16 −40 34 17 459 6.33 154 161 <
Recovery
r. Cerebellum: Culmen 26 −44 −20 22 594 6.08 164 170 ~
Lingual G.* 8 −62 −4 176 4752 7.52 163 171 <
Lingual G. −8 −82 −2 20 540 6.84 164 169 ~
No Depression > Depression
Instructions
Posterior Cingulate −4 −44 10 16 432 −6.47 70 74 ~
Cuneus −8 −76 20 18 486 −6.64 69 95 ~
r. Cuneus 16 −74 16 34 918 −5.66 85 97 ~
Early Speech Prep
l. Caudate −14 −22 26 16 432 −5.87 116 123
Late Speech Prep
l. Lentiform Nucleus −26 8 8 31 837 −6.67 132 142
Recovery
Posterior Cingulate G.* 14 −56 14 55 1485 −6.53 176 190 >
l. Precentral G. −44 −10 40 16 432 −5.89 165 173 ~

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. 1 Post-hoc group contrasts that test whether comorbid participants exhibited similar (~; not significantly different from each other, but both groups are different than control participants), greater (>), or less (<) activation than participants with pure depression (p < .05). The lack of a symbol means that comorbid participants did not exhibit significantly different activation than control participants and participants with pure depression.

* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.

Waugh et al. Biology of Mood & Anxiety Disorders 2012 2:11   doi:10.1186/2045-5380-2-11

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