Table 5

Change-point analysis of the BOLD responses to the social evaluative threat task of participants with and without social anxiety disorder
Region x y z voxels vol (mm3) Peak t change-point onset change-point offset comorbid (~,>,<) social anxiety
Social Anxiety > No Social Anxiety
Instructions
Cerebellum: Declive* 8 −58 −14 325 8775 12.52 66 102 <
r. Lingual G.* 26 −74 −2 15 405 5.34 69 79 <
r. Superior Temporal G. 56 −38 4 31 837 7.68 66 83 ~
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
r. Cerebellum: Declive* 26 −56 −20 142 3834 9.03 164 174 <
l. Cerebellum: Declive −20 −62 −20 83 2241 7.45 163 171 ~
No Social Anxiety > Social Anxiety
Instructions
l. Insula −32 8 −4 54 1458 −7.21 68 80
r. Precentral G. 50 −8 22 151 4077 −6.6 67 81 ~
l. Inferior Frontal G.* −52 8 10 66 1782 −6.62 68 86 >
r. Middle Frontal G. 34 52 8 19 513 −7.21 68 82 ~
Cingulate G. 4 −8 34 237 6399 −7.91 66 91
l. Cingulate/Supramarginal G. −26 −26 38 159 4293 −6.94 66 81 ~
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
r. Insula 44 −2 −2 103 2781 −6.67 164 184 ~
l. Insula −40 4 2 124 3348 −7.4 164 184 ~
l. Postcentral G. −38 −20 38 29 783 −6.89 166 177 ~

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. 1 Post-hoc group contrasts that test whether comorbid participants exhibited similar (~; not significantly different from each other, but both groups are different than control participants), greater (>), or less (<) activation than participants with pure social anxiety (p < .05). The lack of a symbol means that comorbid participants did not exhibit significantly different activation than control participants and participants with pure social anxiety.

* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.

Waugh et al.

Waugh et al. Biology of Mood & Anxiety Disorders 2012 2:11   doi:10.1186/2045-5380-2-11

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