Table 6

Change-point analysis of the interaction of depression and social anxiety in BOLD responses to the social evaluative threat task
Region x y z voxels vol (mm3) Peak t change-point onset change-point offset Control Depression Social Anxiety Co-morbid
Comorbid and/or Control > Depression and/or Social Anxiety
Instructions
l. Parahippocampal G −40 −38 −2 34 918 7.3 65 82 2.52b −6.09a −8.17a −1.43ab
l. Insula −40 4 −2 28 756 6.84 64 69 7.10c −8.56a −5.08ab −0.16b
l. Insula −38 −16 8 15 405 5.77 70 78 3.26b −6.15a −6.46a −2.08ab
l. Insula −40 −8 20 195 5265 8.47 64 79 2.25b −9.35a −9.24a −4.41a
r. Insula* 50 −14 14 30 810 5.78 65 71 2.56b −7.62a −7.50a 1.00b
l. Precentral G. −38 8 22 15 405 5.99 65 75 0.03b −4.14ab −6.87a 0.26b
Early Speech Prep
l. Insula −50 −34 22 36 972 5.89 115 121 9.46c −11.72a −1.47b 2.00b
Late Speech Prep
l. Lentiform Nucleus −32 4 −2 15 405 5.58 148 157 3.51b −3.26a −3.48a 1.39ab
Recovery
l. Middle Temporal G.* −44 −38 2 36 972 7.3 160 170 4.01b −7.12a −6.40a 2.08b
l. Precentral G. −38 −14 32 23 621 7.07 164 177 4.36b −8.80a −4.96a −3.08a
Depression and/or Social Anxiety > Comorbid and/or Control
Instructions
Cerebellum: Declive* 8 −62 −20 14 378 −5.38 90 95 −7.42a 10.43c 26.22d 2.94b
Cuneus* −8 −68 4 446 12042 −7.94 65 84 3.28a 27.79c 29.39c 12.44b
r. Inferior Frontal G. 40 20 −10 15 405 −6.07 69 81 −11.20a 7.13c −4.78b −8.58ab
r. Insula 40 4 −4 23 621 −6.57 71 84 −11.09a 8.04b −7.03a −7.09a
r. Cuneus* 22 −76 8 37 999 −6.06 67 79 −1.70a 15.35b 21.56c 3.66a
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
Lingual G. 8 −56 −4 448 12096 −7.4 161 172 −3.95a 27.24c 18.43bc 16.44b
Precuneus* −2 −68 26 21 567 −6.21 164 171 −6.24a 24.31c 23.38c 12.11b

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. Different subscripts represent significantly differences between the groups, calculated using simple slopes analyses on the beta coefficients (presented here) from the multiple regression models.

* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.

Waugh et al.

Waugh et al. Biology of Mood & Anxiety Disorders 2012 2:11   doi:10.1186/2045-5380-2-11

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