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Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation

Lori Lowthert1, Janine Leffert1, Aiping Lin2, Sheila Umlauf3, Kathleen Maloney1, Anjana Muralidharan1, Boris Lorberg1, Shrikant Mane3, Hongyu Zhao4, Rajita Sinha1, Zubin Bhagwagar15 and Robert Beech1*

Author Affiliations

1 Department of Psychiatry, New Haven, CT, 06511, USA

2 Keck Foundation Biotechnology Biostatistics Resource, New Haven, CT, 06511, USA

3 Center for Genome Analysis, New Haven, CT, 06511, USA

4 Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, 06511, USA

5 Neuroscience Global Clinical Research, Bristol-Myers Squibb, Wallingford, CT, 06492-1996, USA

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Biology of Mood & Anxiety Disorders 2012, 2:15  doi:10.1186/2045-5380-2-15

Published: 12 September 2012

Additional files

Additional file 1:

Table S1. Fold difference and p-value for each of 127 genes, grouped by cluster, that showed a significant group x time interaction (i.e. difference in degree or direction of change between lithium-responders and non-responders) after FDR correction for multiple testing , and a fold-difference ≥ 1.3 between lithium responders and non-responders at least one time-point after treatment initiation.

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