Statistical parametric map illustrating whole brain activation associated with reappraisal of emotional responses to negative IAPS photographs (regulate negative > look negative). The cluster in the dorsal medial prefrontal cortex (mPFC; within the red circle) showed a significant relationship with regulatory success based on subjective responses to IAPS photographs (r=.21, p=.04). Maximal voxel MNI coordinates for medial prefrontal cluster: 0, 10, 60; 241 voxels, t=6.32, p<.001. The cluster in the left dorsolateral prefrontal cortex (dlPFC), maximal voxel MNI coordinates for dlPFC cluster: -42, 8, 52; 198 voxels, t=7.11, p<.001, showed a marginally significant relationship with regulatory success (r=.18, p=.07). A third cluster (not visible here) was located in the inferior parietal cortex and had maximal voxel MNI coordinates -50, -58, 46; 481 voxels, t=6.98, p<.001.
Minkel et al. Biology of Mood & Anxiety Disorders 2012 2:22 doi:10.1186/2045-5380-2-22