Exaggerated swim-induced corticosterone and normal responses to swim stressors in Kv4.2 knockout (KO) mice. (A) Genotypes did not differ in percentage immobility during a single 6-minute forced-swim exposure (n = 9-13/genotype). (B) KO mice had significantly raised serum corticosterone levels after the single forced-swim exposure (n = 9-13/genotype). (C) Genotypes had a similar increase in percentage immobility increased over 10 × 1-min inescapable forced swim exposures (n = 14-18/genotype). Data are mean ± SEM. **P < 0.01.
Kiselycznyk et al. Biology of Mood & Anxiety Disorders 2012 2:5 doi:10.1186/2045-5380-2-5