Table 1

Empty-cage behaviors, physical health, sensory reflexes, and neurological functions

Empty-cage behaviorsa

WTb

KOc


Freezing

0

0

Trembling

0

0

Sniffing

100

100

Licking

0

0

Rearing

80

100

Jumping

0

0

Seizure

0

0

Defecation

60

25

Urination

0

0

Head bobbing

0

0

Circling

0

0

Abnormal gait

0

0

Retropulsion

0

0

Physical health

Missing whiskers

0

0

Bald patches

0

0

Exopthalmus

0

0

Straub tail

0

0

Kinked tail

0

0

Kyphosis

0

0

Lordosis

0

0

Body weight, ge

23.6 ± 0.8

23.9 ± 1.3

Core body temp, °Ce

36.2 ± 0.3

36.8 ± 0.1

Sensory reflexes

Approach response

100

100

Touch response

100

100

Palpebral response

100

100

Pinna reflex

100

100

Tail pinch response

100

100

Motor, neurological

Splayed limbs

100

100

Forepaw clutch

0

0

Hind-paw clutch

0

0


aData denote the percentage of animals showing a response unless specified otherwise,

bWild-type.

cKnockout.

eMean ± SD.

Kiselycznyk et al. Biology of Mood & Anxiety Disorders 2012 2:5   doi:10.1186/2045-5380-2-5

Open Data