Table 3

Between-group comparison of activity across symptom provocation and cognitive-emotional studies
Region Hemisphere Talairach BA Volume (mm3)
x y z
    PTSD > Controls
Whole Brain Analysis
Dorsal ACC R 17.3 38.35 15.53 32 672
Mid/Dorsal ACC R 3.49 −3.51 34.37 24 400
Superior Temporal Gyrus L −63.02 −47.37 18.13 22 152
Supplementary Motor Area L −22.02 −1.55 57.56 6 112
Whole Brain + ROI Analysis
Amygdala R 22.86 1.06 −13.32 -- 1328
Amygdala L −25.95 −0.02 −17.87 -- 1136
Dorsal ACC R 17.33 38.35 15.44 32 640
Mid/Dorsal ACC R 3.61 −3.18 34.29 24 288
Medial Frontal Gyrus (dmPFC) R 1.08 31.44 37.87 8 216
Superior Temporal Gyrus L −63.15 −47.34 18.13 22 144
    Controls > PTSD
Whole Brain Analysis
Medial Frontal Gyrus (vmPFC) R 3.07 36.09 −6.69 11 984
Thalamus L −4.12 −14.12 17.89 -- 480
Thalamus R 12.06 −12.03 1.97 -- 464
Inferior Frontal Gyrus R 16.02 21.76 −12.36 47 440
Middle Occipital Gyrus L −31.42 −86.95 −1.35 18 392
Medial Frontal Gyrus R 6.23 48.66 9.06 10 344
Middle Temporal Gyrus R 45.03 −68.88 13.16 39 336
Inferior Frontal Gyrus R 45.79 15.16 10.21 44 304
Precuneus R 24.34 −56.37 38.59 7 280
Cerebellum R 35.16 −82.16 −20 -- 272
Medial Frontal Gyrus R 11.89 42.19 24.43 9 272
Fusiform Gyrus L −51.87 −47.57 −15.78 37 256
Precuneus R 25.76 −84.66 39.71 19 248
Superior Temporal Gyrus L −39.88 −23.07 5.88 13 144
Cerebellum R 20 −47.03 −14.64 -- 128
Inferior Frontal Gyrus R 41.45 39.85 7.14 46 112
Whole Brain + ROI Analysis
Pregenual ACC R 5.17 44.99 14.35 32 1824
Medial Frontal Gyrus (vmPFC) R 3.11 36.03 −6.34 11 864
Thalamus L −4.12 −14.11 17.88 -- 480
Thalamus R 12.01 −12.01 2 -- 456
Inferior Frontal Gyrus R 16.14 21.75 −12.28 47 424
Middle Occipital Gyrus L −31.35 −86.97 −1.34 18 384
Dorsal ACC L −6.43 9.14 25.01 24 368
Middle Temporal Gyrus R 44.97 −68.82 13.1 39 328
Superior Frontal Gyrus L −23.94 50.88 8.8 10 256
Fusiform Gyrus L −51.75 −47.62 −15.77 37 248
Thalamus L −7.65 −6.83 7.93 -- 248
Precuneus R 24.44 −56.35 38.82 7 248
Inferior Frontal Gyrus R 45.69 14.86 10.31 44 240
Precuneus R 25.73 −84.68 39.86 19 216
Cerebellum R 35.01 −82 −20 -- 208
Superior Temporal Gyrus L −39.98 −22.77 5.98 13 120

P < .05 FDR-corrected, cluster activation extent ≥ 100 mm3. ACC = anterior cingulate cortex, BA = Brodmann area, dmPFC = dorsomedial prefrontal cortex, L = left, R = right, vmPFC = ventromedial prefrontal cortex.

Hayes et al.

Hayes et al. Biology of Mood & Anxiety Disorders 2012 2:9   doi:10.1186/2045-5380-2-9

Open Data