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Volume 2 (2012) - September 2012

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Research   Open Access Highly Accessed

Correlations between psychological tests and physiological responses during fear conditioning and renewal

Karen G Martínez, Melissa Castro-Couch, José A Franco-Chaves, Brenda Ojeda-Arce, Gustavo Segura, Mohammed R Milad, Gregory J Quirk Biology of Mood & Anxiety Disorders 2012, 2:16 (17 September 2012)

Abstract | Full text | PDF | PubMed

Research   Open Access Highly Accessed

Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation

Lori Lowthert, Janine Leffert, Aiping Lin, Sheila Umlauf, Kathleen Maloney, Anjana Muralidharan, Boris Lorberg, Shrikant Mane, Hongyu Zhao, Rajita Sinha, Zubin Bhagwagar, Robert Beech Biology of Mood & Anxiety Disorders 2012, 2:15 (12 September 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Lithium has differing effects between individuals being treated for depression. The biological basis for this difference has now been shown at the genetic level, with non-responders showing different levels of gene activation- most notably in genes associated with apoptosis.