Correlates of anhedonia.A: Correlation coefficients for all pairwise correlations between questionnaire measures. All are highly significant (p<.01), except for the correlation between anhedonic depression and anxious anxiety, denoted by a red dot. B: Hierarchical weighted regression analysis across all datasets, involving all 255 participants with a full set of BDI, BDA and MASQ scores. The plots shows the linear coefficients between anhedonic depression (AD) score and the reward sensitivity and learning rate parameters ρ and ϵ. Each bars shows one linear coefficient; the red error bars indicate ± 1 standard error; and the green error bars indicate the 99.4% confidence interval (corresponding to a Bonferroni corrected level p=.05/8). AD is significantly and negatively correlated with the reward sensitivity ρ, but not significantly correlated with the learning rate ϵ. C: Scatter plot of anhedonic depression against reward sensitivity. Size of dots scale with weight (inference precision). D: Scatter plot of reward sensitivity vs. learning rate. E: Significance of correlations across parameter estimates from 70 surrogate datasets. There is a consistent and stably significant correlation between AD and reward sensitivity ρ, but not between AD and learning rate ϵ.
Huys et al. Biology of Mood & Anxiety Disorders 2013 3:12 doi:10.1186/2045-5380-3-12