Table 1

Neural activation decrease over time in the phobic group
Structure H x y z Zmax pfwe
Phobia gt neutral
Middle temporal gyrus L −45 14 −29 4.92 .029E
insula L −30 20 −8 3.30 .069+
caudate nucleus R 21 −16 22 3.45 .037
dlPFC L −24 32 46 3.74 .071+
dmPFC L −6 29 40 4.79 .001
.050E+
dmPFC L −3 53 7 3.99 .017
dmPFC R 6 47 4 4.33 .004
dmPFC R 6 32 43 3.33 .098+
rACC L −3 50 7 4.00 .006
rACC R 6 44 4 3.87 .009
vlPFC L −39 29 13 4.14 .011
vlPFC L −45 17 13 3.57 .071+
vmPFC L −3 56 −11 4.05 .008
vmPFC R 9 59 −14 3.76 .021
Neutral gt phobia
no significant results
Phobia gt fear
insula L −39 −1 4 3.18 .097+
vlPFC L −45 8 10 3.94 .023
vlPFC R 48 17 1 3.57 .076+
Fear gt phobia
no significant results
Phobia gt disgust
rACC R 6 38 13 3.94 .031
Disgust gt phobia
vmPFC R 9 29 −23 3.57 .034
vmPFC R 3 23 −23 3.52 .039

Neural activation decrease over the course of symptom provocation for phobic compared with neutral pictures for exploratory whole brain analyses (marked with E) and regions of interest analyses (pfwe < .05); tendentially significant results pfwe < .1 are marked with +; all coordinates (x, y, z) are given in MNI space. H, hemisphere; L, left R, right; Zmax, maximum Z-value pfwe, fwe-corrected p-value (small-volume correction).

Hermann et al.

Hermann et al. Biology of Mood & Anxiety Disorders 2013 3:16   doi:10.1186/2045-5380-3-16

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