Reasearch Awards nomination

Email updates

Keep up to date with the latest news and content from Biology of Mood & Anxiety Disorders and BioMed Central.

Open Access Highly Accessed Research

Emotion regulation in social anxiety disorder: behavioral and neural responses to three socio-emotional tasks

Michal Ziv*, Philippe R Goldin, Hooria Jazaieri, Kevin S Hahn and James J Gross

Author Affiliations

Department of Psychology, Stanford University, Jordan Hall, Bldg. 420, 94305-2130 Stanford, CA, USA

For all author emails, please log on.

Biology of Mood & Anxiety Disorders 2013, 3:20  doi:10.1186/2045-5380-3-20

Published: 4 November 2013

Abstract

Background

Social anxiety disorder (SAD) is thought to involve deficits in emotion regulation, and more specifically, deficits in cognitive reappraisal. However, evidence for such deficits is mixed.

Methods

Using functional magnetic resonance imaging (fMRI) of blood oxygen-level dependent (BOLD) signal, we examined reappraisal-related behavioral and neural responses in 27 participants with generalized SAD and 27 healthy controls (HC) during three socio-emotional tasks: (1) looming harsh faces (Faces); (2) videotaped actors delivering social criticism (Criticism); and (3) written autobiographical negative self-beliefs (Beliefs).

Results

Behaviorally, compared to HC, participants with SAD had lesser reappraisal-related reduction in negative emotion in the Beliefs task. Neurally, compared to HC, participants with SAD had lesser BOLD responses in reappraisal-related brain regions when reappraising faces, in visual and attention related regions when reappraising criticism, and in the left superior temporal gyrus when reappraising beliefs. Examination of the temporal dynamics of BOLD responses revealed late reappraisal-related increased responses in HC, compared to SAD. In addition, the dorsomedial prefrontal cortex (DMPFC), which showed reappraisal-related increased activity in both groups, had similar temporal dynamics in SAD and HC during the Faces and Criticism tasks, but greater late response increases in HC, compared to SAD, during the Beliefs task. Reappraisal-related greater late DMPFC responses were associated with greater percent reduction in negative emotion ratings in SAD patients.

Conclusions

These results suggest a dysfunction of cognitive reappraisal in SAD patients, with overall reduced late brain responses in prefrontal regions, particularly when reappraising faces. Decreased late activity in the DMPFC might be associated with deficient reappraisal and greater negative reactivity.

Trial registration

ClinicalTrials.gov identifier: NCT00380731

Keywords:
Social anxiety; Emotion regulation; Reappraisal; fMRI; DMPFC; Temporal dynamics