Figure 2.

A priori region of interest: Anterior insula. A) Voxel-wise main effect of group for the contrast Match Faces > Match Shapes, along with Match Angry > Match Shapes, Match Fear > Match Shapes, and Match Happy > Match Shapes, showing bilateral anterior insula (aINS) displayed on statistical F-map at p < 0.05; cluster size >10 contiguous voxels (family-wise error corrected for multiple comparisons across small volumes of interest). Color scale reflects F-score. B) Bar graphs depicting extracted parameter estimates of activation from the aINS ROI within each group showing Generalized Social Anxiety Disorder exhibited greater bilateral anterior insula activation than Healthy Controls (p < 0.05).

Klumpp et al. Biology of Mood & Anxiety Disorders 2013 3:7   doi:10.1186/2045-5380-3-7
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