Open Access Research

Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas

Orna Issler1, Roderick N Carter2, Evan D Paul3, Paul AT Kelly4, Henry J Olverman4, Adi Neufeld-Cohen1, Yael Kuperman1, Christopher A Lowry3, Jonathan R Seckl2, Alon Chen1 and Pauline M Jamieson2*

Author Affiliations

1 Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel

2 Centre for Cardiovascular Science, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK

3 Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA

4 Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK

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Biology of Mood & Anxiety Disorders 2014, 4:1  doi:10.1186/2045-5380-4-1

Published: 21 January 2014

Additional files

Additional file 1:

Serotonergic and corticosteroid gene expression in control and CRFR2-null mice in response to ARS or CVMS.

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