CRFR2-null mice exhibit increased anxiety-like behaviour 48 hours after ARS in the OF test. Under basal conditions (A), immediately following ARS (B), or after CVMS (C), no differences were observed in behaviour between CRFR2-null mice and controls. However, when CVMS mice (D) or naïve mice (E) were exposed to ARS and tested 24 to 48 h later, CRFR2-null mice showed increased anxiety-like behaviour compared with control mice. Data expressed as mean ± SEM. N = 10 to 14 for A-D, N = 5 to 8 for E. *P < 0.05, **P < 0.01, ***P < 0.001, ~P = 0.085, compared with control.
Issler et al. Biology of Mood & Anxiety Disorders 2014 4:1 doi:10.1186/2045-5380-4-1